S4 E26: Microdosing GLP-1s / Semaglutides: A Tool For Reducing Inflammation, Weight Loss, & Insulin Resistance

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S4 E26: Microdosing GLP-1s / Semaglutides: A Tool For Reducing Inflammation, Weight Loss, & Insulin Resistance
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Today’s episode topic is a LONG time coming, and it’s something that is both intriguing + triggering: GLP1’s and semaglutide peptides. 

I know there are sooo many strong opinions about GLP-1s (especially in the holistic health space). My goal is to bring a fresh perspective to these medications – specifically, as to how they can impact women’s metabolic health in a positive way, whether you’re dealing with PCOS, insulin resistance or in perimenopause.

I’m diving into the nitty gritty on GLP-1s peptides & how they *actually* work, and the concept of microdosing GLP-1s. I’m also discussing naturally-occurring GLP-1s vs. medications like semaglutide and tirzepatide, how peptides positively affect inflammation, insulin resistance during perimenopause, common myths and ‘fear mongering’ surrounding GLP-1s, and more.

If you’ve ever felt torn about GLP-1 medications, you’re NOT alone. It’s important to realize that these aren’t just another ‘quick fix’, and personalization is key here!

If you’re struggling with the unique metabolic storm that is perimenopause, learn more about how our team can help you HERE. We would love to support you with your metabolic and hormone health so you can heal + THRIVE in your everyday life!

Episode Recap:

  • Understanding GLP-1s + how they work {4:22}
  • ‘Naturally’ occurring GLP-1s vs. prescription GLP-1s {6:20}
  • Factors that contribute to lowering your body’s natural GLP-1 {9:01}
  • Supporting & boosting your body’s natural GLP-1 production {13:03}
  • Why GLP-1s can be key in perimenopause + how these can support insulin resistance and lowering inflammation {16:14}
  • Common myths & fears surrounding GLP-1s {18:17}
  • Microdosing GLP-1s + how we’ve supported clients in this process {24:55}
  • Why microdosing GLP-1s can support hormonal & metabolic shifts during perimenopause {35:38}
  • Why GLP-1s aren’t a one-size-fits-all & personalization matters {39:44}
  • Options for getting GLP-1s prescribed for you {43:36}

Links & References:

**Disclaimer: The information shared in this podcast is NOT meant to be taken as individual or medical advice. Please seek the advice of your physician or healthcare provider regarding any medical condition or treatment.

More About the Fueled & Free Podcast:

Hosted by Margaret Powell, a Holistic Nutritionist, The Fueled & Free Podcast is a women’s health podcast that helps you cut through the noise of the wellness world, ditch diet culture & reclaim your metabolism.

Informative and relatable wisdom + guidance for the everyday woman, we cover topics on nutrition, hormones, gut health, thyroid health, nervous system regulation tools, motherhood, and more. New episodes release every Wednesday! Connect with Margaret on Instagram @margaretannpowell or email fueledandfreepodcast@gmail.com. To learn more about working with Margaret, head to https://fueledandfree.com.

Lots of Love,

At Fueled & Free Nutrition, we believe you deserve real answers about your health—not just band-aid solutions.
Whether you’re struggling with gut issues, perimenopause or menopause symptoms, low energy, or hormonal imbalances, we’re here to help you rebuild your resilience and feel like yourself again. Let’s uncover what’s really going on so you can finally move forward with confidence and ease.

Hey, I'm Margaret

I'm a Certified Holistic Nutritionist + Holistic Health Coach, Functional Diagnostic Nutritionist and owner of an integrative virtual wellness clinic that has helped hundreds of women on their journey to optimal health.

I know from my own personal health journey that it's possible to reclaim my body after years of struggling. I was confused and overwhelmed, dismissed by health providers who didn't take the time to understand the "why" behind my symptoms. Then I discovered Functional Nutrition and worked through the process of unraveling the root causes behind my struggles, everything changed.

Now I'm here to help you do the same!

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