S5 E6: When Microdosing GLP-1s Isn’t Enough For Fat Loss: Why Needing a Higher Dose Isn’t Failure

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S5 E6: When Microdosing GLP-1s Isn’t Enough For Fat Loss: Why Needing a Higher Dose Isn’t Failure
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In this episode of the Fueled & Free Podcast, Margaret shares her personal experience with microdosing GLP-1 peptides, and observations she’s had having coached clients who are microdosing GLP peptides. 

She breaks down how microdosing can minimize side effects, support appetite regulation, and improve metabolic health, while emphasizing that it’s not a one-size-fits-all solution when it comes to fat loss. 

Margaret also dives into the nuances of insulin resistance, hormone balance, and gut health — explaining why each person’s response to GLP-1s is unique, i.e. why some need a higher dose to get their body to respond. 

This episode challenges the misconception that needing a higher dose means failure, and instead reframes it as part of a personalized journey toward better health.

Episode Recap:

  • What microdosing really means and why it’s a smart, gentle starting point {01:42}
  • Why microdosing can fall short for fat loss if deeper metabolic issues exist {03:47}
  • Five reasons your body may not respond on a low dose (insulin resistance, receptor sensitivity, thyroid, undereating, gut health) {09:18}
  • How to know when it’s time to move from microdosing to a therapeutic dose {17:09}
  • Why needing a higher dose is not failure—it’s feedback from your body {24:44}
  • The importance of flexibility over rigidity in your dosing journey {31:21}
  • Why the microdosing phase still matters, even if you eventually titrate {32:00}

Links & References:

Connect with me on Instagram @margaretannpowell

**Disclaimer: The information shared in this podcast is NOT meant to be taken as individual or medical advice. Please seek the guidance of your physician or healthcare provider regarding any medical condition or treatment.

More About the Fueled & Free Podcast:

Hosted by Margaret Powell, a Holistic Nutritionist, The Fueled & Free Podcast is a women’s health podcast that helps you cut through the noise of the wellness world, ditch diet culture & reclaim your metabolism.

Informative and relatable wisdom + guidance for the everyday woman, we cover topics on nutrition, hormones, gut health, thyroid health, nervous system regulation tools, motherhood, and more. New episodes release every Wednesday! Connect with Margaret on Instagram @margaretannpowell or email fueledandfreepodcast@gmail.com. To learn more about working with Margaret, head to https://fueledandfree.com.

Lots of Love,

At Fueled & Free Nutrition, we believe you deserve real answers about your health—not just band-aid solutions.
Whether you’re struggling with gut issues, perimenopause or menopause symptoms, low energy, or hormonal imbalances, we’re here to help you rebuild your resilience and feel like yourself again. Let’s uncover what’s really going on so you can finally move forward with confidence and ease.

Hey, I'm Margaret

I'm a Certified Holistic Nutritionist + Holistic Health Coach, Functional Diagnostic Nutritionist and owner of an integrative virtual wellness clinic that has helped hundreds of women on their journey to optimal health.

I know from my own personal health journey that it's possible to reclaim my body after years of struggling. I was confused and overwhelmed, dismissed by health providers who didn't take the time to understand the "why" behind my symptoms. Then I discovered Functional Nutrition and worked through the process of unraveling the root causes behind my struggles, everything changed.

Now I'm here to help you do the same!

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